Dr Ccori MARTINEZ TUPPIA
Ccori currently works as senior scientist at Centre of Excellence Nutrition, Microbiota & Health from Lesaffre RD&I.
She works in projects associated with characterization & substantiation of microbial-based solution in health & nutrition applications. By using in vitro models, she focuses on understanding gut microbiome modulation and its interaction with host.
Before joining Lesaffre, Ccori worked as principal research scientist at Ysopia bioscience which develops live biotherapeutics products based on commensal strict anaerobic bacteria to treat obesity and relieve IBS-associated symptoms. Her mission was to elucidate the physiology and potential of Christensenella minuta. She also participated in the preclinical development of drugs by assessing the impact of candidate strains on gut microbiota ecosystem by in vitro & in vivo approaches.
She hold a postdoctoral position at Lallemand company (based at Montréal, CA). Her work focused on the implementation of a phenotypic and genotypic workflow to characterize and quantify LAB probiotic strains in complex matrices.
In 2015, Ccori completed a Ph.D in Microbiology of University of Bordeaux. Her Ph.D project was cofunded by INRAE and Lallemand company. Her work focused on studying Fumonisin B1 mycotoxin degradation by corn silage microbiota. For this, she performed high throughput sequencing approaches and in vitro screening to identify taxonomic profiles and endemic microbial agents potentially associated with mycotoxin degradation.
Next Generation Microbiome research: effect of keystone anaerobic bacteria on gut microbiome modulation
Gut microbiome is a complex microbial community that plays a key role on health and disease. This community will be involved in nutrient metabolism, maintenance of the intestinal epithelial barrier and local and systemic immunomodulation.
Several factors will dictate gut microbiome composition and balance. Some species, considered as keystone microbes, will play a specific niche by exerting multiple microbe-microbe interactions and carrying unique functions that are essential for the balance of the microbiota. Consequently, the depletion of keystone microbes will strongly contribute to an unbalanced or dysbiotic ecosystem and impact on host-inflammatory responses.
In this review, through 2 study cases (assessment of Christensenella sp. and Faecalibacterium sp.), we highlight the importance of identifying & characterizing keystone strict anaerobic bacteria as well as their role in gut microbiome modulation. We also address current and future tools and models needed to identify missing functions in the gut carried by these species.
Further investigation on keystone gut microbes will allow to understand the microbiome dynamics in non-communicable disease as well as inflammatory disorders. Finally, their utilization as biotic strategy may provide different assets compared to classical probiotics. For instance, optimal ecosystem adaptation, ability to restore microbiota balance and cross-feeding capacity.