Pr. Juan HERNANDEZ
Dr Hernandez graduated from the National Veterinary School of Maisons-Alfort (France) in 1999. He completed a residency program at Université de Montréal and is diplomate of the American College of Veterinary Internal Medicine since 2006.
He completed his research formation with a Master and a PhD on canine intestinal immunology in the context of IBD. Currently, he is Full-time professor / Head of Internal Medicine Service at the Veterinary Teaching Hospital, Oniris, Nantes, France with a particular interest in canine gastroenterology.
His research activity is inserted in the INRAE MICALIS unit and he works on understanding the interactions between the gut microbiota and the host in the context of intestinal inflammation in dogs.
Gut microbiota and intestinal inflammation in dogs
Like humans, dogs suffer from inflammatory enteropathies (IE). The role of the composition and diversity of the gut microbiota is a key factor in the development and maintenance of intestinal inflammation.
Studies in dogs show that dysbiosis is important during IE with a reduction in the abundance of Bacteroidetes and Firmicutes and an increase in the abundance of Enterobacteriaceae and Proteobacteria.
Several mechanisms explaining the link between dysbiosis and inflammation have been elucidated but it is currently a completely open field of research.
The role of dysbiosis in bile acid dysmetabolism has been described in several species including dogs. The importance of the role of short-chain fatty acids produced by bacteria on the intestinal inflammatory process is well documented. The tryptophan and indole metabolism pathway is less explored in dogs.
Finally, the role of proteolytic homeostasis is an active area of research in human and dogs with IE.