Pr. Leluo GUAN


Dr. Leluo Guan is one of the pioneer researchers in cattle gut microbiome. Dr. Guan’s research program focuses on

1). Elucidation of the molecular mechanisms of host-microbial interactions by characterization of bovine gut microbial ecology and its functions using metagenomics/metatranscriptomics approaches, and host gene expression using a functional genomics approach

2). Association between gut microbiome and feed efficiency, methane emission, productivity and gut immunity development in beef and dairy cattle; 3). Study of the bovine transcriptome, proteome, and non-coding microRNAs and their roles in economically important traits.

Dr. Guan is the author or co-author of 242 peer-reviewed publications and 8 book chapter with H-index of 63.0. She has secured > 33.9 M research funding (>10.5 as PI and >23.4 M as Co-I) and has trained a total of 38 graduate students and 21 postdocs.

Department of Agricultural, Food and Nutritional Science, University of Alberta

Canada 🇨🇦 

Relevant publications

Song YLi F, Fischer-Tlustos AJ, Neves ALA, He Z, Steele MA, Guan LL. 2021. Metagenomic analysis revealed the individualized shift in ileal microbiome of neonatal calves in response to delaying the first colostrum feeding. J Dairy Sci. 104 (8): 8783-8797.

Malmuthuge N, Guan LL. 2021 Noncoding RNAs: Regulatory Molecules of Host–Microbiome Crosstalk. Trends in Microbiology. 29 (8):713-724

Guo W, van Niekerk JK, Zhou M, Steele MA, and Guan LL. 2021. Longitudinal assessment revealed the shifts in rumen and colon mucosal attached microbiota of dairy calves during weaning transition. J Dairy Sci. 104 (5): 5948-5963

Ma T, Villot C, Renaud D, Skidmore A, Chevaux E, Steele M, Guan LL. 2020. Linking perturbations to temporal changes in diversity, stability, and compositions of neonatal calf gut microbiota: prediction of diarrhea. ISME J 14: 2223–2235.

Ma T, O’Hara É, Song Y, Fischer AJ, He Z, Steele MA, Guan LL. 2019. Altered mucosa-associated microbiota in the ileum and colon of neonatal calves in response to delayed first colostrum feeding. J Dairy Sci. 102(8):7073-7086.

Malmuthuge N, Liang G, Guan LL. 2019. Regulation of rumen development in neonatal ruminants through microbial metagenomes and host transcriptomes. Genome Biology.  Aug 23;20(1):172. doi: 10.1186/s13059-019-1786-0.

Malmuthuge N, Liang G, Griebel PJ, Guan LL. 2019. Taxonomic and functional composition of the small intestinal microbiome in neonatal calves provide a framework for understanding early life gut health. Appl Environ Microbiol.Mar 6;85(6). pii: e02534-18. doi: 10.1128/AEM.02534-18.

Malmuthuge NGuan LL. 2017. Understanding the gut microbiome of dairy calves: Opportunities to improve early-life gut health. J Dairy Sci. 100(7): 5996-6005. doi: 10.3168/jds.2016-12239.


Microbiome solutions: intervention opportunities to improve neonatal calf health and performance

More and more evidence indicate that the colonization and establishment of calf gut microbiome is a complex process and the establishment a stable and the maintenance of a balanced gut microbiota during early life can directly and indirectly influence animal’s various gut functions that can impact animals’ development and growth, and have a lifelong impact on their performance.

Therefore, the intervention of gut microbiome to prevent and/or restore the microbial dysbiosis during early life of calves has been considered as one of effective approaches to improve gut health. Direct fed microbes (live naturally existing microbes that can benefit host animals on health and production performance) with psychobiotic (a type of probiotic that affect cognitive and behavioral functions of the host via the gut-brain axis) function can be one of novel microbiome solutions to target and alter the microbiome dysbiosis.

This presentation will highlight to date research of direct fed microbes and psychobiotics and their potential implications in improving calf health and productivity through manipulation of the gut microbiome in calves.